Cracking glycan-lectin interactions to target immunosuppressive macrophages in triple-negative breast cancer. Contributions: Identified glycan epitope diversity through reverse-phase microarrays. Implemented key protocols, including total carbohydrate quantitation and lectin enrichment.

Targeting a ‘toolbox’ of human microbiome O-Glycan-Selective proteins towards new approaches in cancer research. Contributions: Conducted bioinformatic analysis for protein target selection. Produced a library of proteins with relevant O-glycopeptidases and their appended recognition modules. Assigned glycan specificity using glycan and glycoprotein microarrays.

Building Networks to Excel in Glycosciences. Contributions: Engaged in training on glycan microarray technology as a PhD student. Assisted in scientific dissemination and organized multiple events to promote the project.

Developing antibody based therapies directed to Cancer-specific targets Contributions: Analyzed glycan-binding specificity of preclinical antibodies for cancer immunotherapy using glycan microarrays. Notably, BioNTech acquired one of CellmAbs´ preclinical antibody candidates and additional ADC technology.

Targeting glycan specificity of tumor-specific antibodies for development of effective anti-cancer strategies. Contributions: Performed glycan-binding specificity analysis of preclinical antibodies using glycan microarrays, aiding in the development of anti-cancer strategies.

Glycan-human microbiome interaction: glycan diversity and recognition in the human gut with impact on health and nutrition. Contributions: Produced target proteins and performed structural elucidation using X-ray crystallography. Characterized protein-glycan interactions through glycan microarrays and microscale thermophoresis (MST).

An integrative structural biology approach to characterise the protein-carbohydrate microbial recognition. Contributions: Optimized protein constructs using molecular biology techniques. Refined protein expression and purification conditions through thermal shift assays. Successfully crystallized and solved novel protein structures. Characterized molecular interactions using MST, isothermal titration calorimetry (ITC), and glycan microarrays.

Targeting p53 family proteins: on the route to new anticancer agents. Contributions: Prepared protein crystals using various crystallization techniques. Successfully solved the 3D structure of a mutant p53 protein, contributing to the rational design of novel molecules with potential applications in cancer treatment.